{"product_id":"caffeine-earrings-gold-vermeil","title":"caffeine earrings | gold vermeil","description":"\u003ch2\u003eCaffeine earrings | 18K gold vermeil\u003c\/h2\u003e\n\u003cp\u003eIf you have ever explained adenosine to a room that only wanted to know why the coffee works, this is your molecule. Caffeine is the structure almost everyone uses daily and almost nobody can draw. In gold, it reads as ornament first and chemistry second, which is usually the right order.\u003c\/p\u003e\n\u003ch2 style=\"margin-top: 2em;\"\u003eThe Science Behind Caffeine\u003c\/h2\u003e\n\u003cp\u003eCaffeine is a methylxanthine, and for most of its history its target was known only by inference. That changed in 2011, when a thermostabilised human adenosine A2A receptor was crystallised with caffeine bound and solved at 3.6 Å, alongside two related ligands of the same site. The structure put caffeine in the pocket adenosine itself occupies, in a receptor conformation that stays inactive while occupied. That is the structural picture of a competitive antagonist: the site is held and the signal deferred, while the sleep debt behind it keeps accruing.\u003c\/p\u003e\n\u003ch2 style=\"margin-top: 2em;\"\u003eWho It Is Given To\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003epharmacologists and structural biologists working on G protein-coupled receptors\u003c\/li\u003e\n\u003cli\u003eneuroscientists and sleep researchers\u003c\/li\u003e\n\u003cli\u003echemistry and pharmacology teachers who use caffeine as the worked example of competitive antagonism\u003c\/li\u003e\n\u003cli\u003eanyone marking the end of a thesis, a residency, or a night-shift year that ran on the molecule\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 style=\"margin-top: 2em;\"\u003eExplore Related Molecules Jewelry\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/sciencejewelry1824.shop\/products\/caffeine-earrings\"\u003eCaffeine earrings | silver\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/sciencejewelry1824.shop\/products\/caffeine-18k-gold-plated\"\u003eCaffeine necklace | gold vermeil\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/sciencejewelry1824.shop\/products\/caffeine-studs\"\u003eCaffeine studs | silver\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/sciencejewelry1824.shop\/products\/antibody-earrings-gold-vermeil\"\u003eAntibody earrings | gold vermeil\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003csection class=\"product-faq\"\u003e\n\u003ch2 style=\"margin-top: 2em;\"\u003eFAQ\u003c\/h2\u003e\n\u003ch3 style=\"margin-top:1.75em;\"\u003eWhy does caffeine block the adenosine receptor instead of activating it?\u003c\/h3\u003e\n\u003cp\u003eBecause it fits the binding pocket without triggering the conformational change that switches the receptor on. Adenosine accumulates through a waking day and its binding signals sleep pressure. Caffeine competes for the same site, sits there, and leaves the receptor in its inactive state. The 2011 crystal structures made that visible rather than inferred, which is why they are still used as reference points in structure-based design at this receptor family.\u003c\/p\u003e\n\u003ch3 style=\"margin-top:1.75em;\"\u003eHow does gold vermeil hold up on earrings?\u003c\/h3\u003e\n\u003cp\u003eVermeil here is 2.5 microns of 18K gold over solid sterling silver, a thicker gold layer than standard plating. Earrings also see less abrasion than a ring, since nothing rubs against them through the day. Clean with a soft dry cloth, and keep perfume, hairspray and cleaning products off the metal.\u003c\/p\u003e\n\u003ch3 style=\"margin-top:1.75em;\"\u003eWhat are the size, material and finding specs?\u003c\/h3\u003e\n\u003cp\u003e18K gold vermeil over a sterling silver core, a 14 mm molecule on 17.5 mm gold vermeil hoops. Nickel-free and hypoallergenic. Free worldwide DHL Express in 1-5 business days, with all import duties and taxes covered. 30-day “Love It or Return It” returns.\u003c\/p\u003e\n\u003ch3 style=\"margin-top:1.75em;\"\u003eIs there a silver version?\u003c\/h3\u003e\n\u003cp\u003eYes. The same caffeine earrings come in \u003ca href=\"https:\/\/sciencejewelry1824.shop\/products\/caffeine-earrings\"\u003esterling silver\u003c\/a\u003e at the same 14 mm size on the same 17.5 mm hoops. Choose the finish the recipient already wears. Both versions carry the same design and the same meaning.\u003c\/p\u003e\n\u003c\/section\u003e\n","brand":"sciencejewelry1824","offers":[{"title":"Default Title","offer_id":56916449657218,"sku":"ER0056-GV","price":200.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1411\/4806\/files\/caffeine-earrings-gold-vermeil-render.png?v=1789676022","url":"https:\/\/sciencejewelry1824.shop\/products\/caffeine-earrings-gold-vermeil","provider":"sciencejewelry1824","version":"1.0","type":"link"}