€ 150
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Adrenaline necklace | 18k gold vermeil
Jokichi Takamine isolated adrenaline in 1901, making it the first hormone ever crystallised from body tissue. Over a century later it remains the first-line drug in anaphylaxis, the molecule released under acute stress, and the active ingredient in the most consequential auto-injector in modern medicine.
The Science Behind Adrenaline
Adrenaline (epinephrine) is a catecholamine hormone synthesised in the adrenal medulla from the amino acid tyrosine through a four-step pathway. Adrenaline acts on alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors throughout the body. Alpha-1 effects increase vascular resistance and blood pressure. Beta-1 effects increase heart rate and contractility. Beta-2 effects dilate airways and relax vascular smooth muscle in skeletal muscle. Together, these effects prepare the organism for sustained physical effort. In anaphylaxis, adrenaline simultaneously reverses hypotension, restores airway patency, and prevents further mast cell mediator release. The EpiPen auto-injector, developed by biomedical engineer Sheldon Kaplan in the late 1970s, adapted military nerve agent antidote technology for emergency allergy use.
Worn By
- emergency physicians and paramedics who administer adrenaline daily
- allergists and immunologists managing anaphylaxis and acute reactions
- pharmacologists and cardiologists studying adrenergic systems
- athletes and exercise physiologists understanding the stress response
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FAQ
Who would appreciate adrenaline in gold?
Emergency physicians, paramedics, allergists, and anyone for whom adrenaline is central to their work or survival. The gold vermeil version registers as a milestone choice, worn by someone who has administered it when it mattered most. It is refined enough for professional settings and specific enough to signal expertise.
Why is adrenaline the only essential drug in anaphylaxis?
Because it is the only drug that addresses the entire cascade simultaneously. It restores blood pressure through alpha-1 vasoconstriction, opens airways through beta-2 bronchodilation, and stabilises mast cells to prevent further mediator release. Every other drug in anaphylaxis is backup. Adrenaline is irreplaceable and must be given immediately.
What size, material, and chain are included?
28 mm pendant in 18k gold vermeil (sterling silver core with 2.5 micron gold plating), nickel-free and hypoallergenic. 45 cm gold vermeil chain with 5 cm extender. Ships free worldwide via DHL Express in 1-5 business days. Comes ready-to-gift with the 30-day “Love It or Return It” policy.
Is there a silver version at the same size?
Yes. Adrenaline is available in sterling silver at 28 mm. This gold vermeil version and the silver version have the same structure, same 28 mm size, and same scientific meaning. Material is the only difference. Many emergency medicine teams pair both as personal pieces and colleague gifts.
Molecules
Delve into the hidden elegance of science with our meticulously crafted jewelry, inspired by the intricate structures of chemical molecules. Each piece serves as a tactile tribute to the building blocks of life and matter, capturing the allure of atoms and bonds in precious metals. A harmonious fusion of art and science, these creations are more than mere accessories; they're a celebration of the enigmatic beauty that underpins our universe.
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