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Guanine necklace | sterling silver
If you can explain why a Ras mutation drives cancer, you already know more about guanine than the DNA-base level. The G in DNA is the same molecule as the G in GTP, GDP, GTPase signalling, and every G protein-coupled receptor. The reach of the base extends well beyond pairing. As a 24 mm sterling silver pendant.
The Science Behind Guanine
Guanine, formally 2-amino-6-oxopurine, forms three hydrogen bonds with cytosine in the Watson-Crick pair. That third bond makes G-C base pairs more thermally stable than A-T, which is why GC-rich DNA sequences melt at higher temperatures. Beyond DNA, guanine as GTP is the substrate for the GTPase superfamily. G proteins cycle between GDP-bound (inactive) and GTP-bound (active) states. G protein-coupled receptors, which include almost all neurotransmitter and hormone receptors, signal through heterotrimeric G proteins. The Ras oncogene encodes a small GTPase that becomes constitutively active when mutated, locked in the GTP-bound state. The result is uncontrolled cell proliferation, one of the most common driver mutations in human cancer. Guanine crystals also produce iridescence in fish scales.
Who Will Recognise It
- molecular biologists and structural biologists
- cell biologists studying G protein signalling
- cancer biologists working on Ras and other GTPase mutations
- biochemists, structural biologists, and pharmacologists working on GPCRs
The base behind G proteins, Ras, and the thermodynamic strength of every G-C pair.
Explore Related Molecules Jewelry
- Cytosine necklace | silver
- Cytosine-guanine earrings | silver
- Cytosine-guanine necklace | silver
- Cytosine-guanine necklace | gold vermeil
- Adenine necklace | silver
FAQ
Why guanine on its own rather than the C-G pair?
Because the molecule reaches well past base pairing. Guanine as GTP runs every G protein-coupled receptor, every Ras-family GTPase, and most of intracellular signal transduction. People who work on cancer biology, GPCR pharmacology, or signal transduction tend to find the single-base guanine pendant more meaningful than the paired one for that reason. The combined C-G pendant exists separately for buyers who want the pair.
Why is GC content used to compare genomes?
Because GC base pairs are thermally stronger than AT pairs, GC-rich regions of DNA require higher temperatures to denature. That has practical consequences for PCR primer design and for evolutionary genome comparisons: bacterial species can be distinguished by their average GC content, and GC content varies systematically across the human genome in regions called isochores. The thermodynamic difference between two and three hydrogen bonds, scaled across millions of base pairs, becomes a measurable property of the genome itself.
What size is the pendant and what is the return policy?
925 sterling silver, 24 mm pendant on a 45 cm sterling silver chain with a 5 cm extender. Largest of the four DNA bases at this scale. Nickel-free and hypoallergenic. Free worldwide DHL Express in 1-5 business days, with all import duties and taxes covered. 30-day “Love It or Return It” returns.
Are the other DNA bases available in the same style?
All four bases are available as separate sterling silver necklaces: adenine, thymine, cytosine, and guanine. Sizes vary slightly (adenine 21 mm, guanine 24 mm, cytosine and thymine 19 mm). The combined cytosine-guanine pendant exists in both silver and gold vermeil, and matching mix-and-match earring sets exist for both base pairs.
Molecules
Delve into the hidden elegance of science with our meticulously crafted jewelry, inspired by the intricate structures of chemical molecules. Each piece serves as a tactile tribute to the building blocks of life and matter, capturing the allure of atoms and bonds in precious metals. A harmonious fusion of art and science, these creations are more than mere accessories; they're a celebration of the enigmatic beauty that underpins our universe.
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