€ 135
Still questions? Contact us
Ketamine necklace | silver
Ketamine is an NMDA glutamate receptor antagonist that has been used as a dissociative anesthetic since 1970 and has been producing clinical surprises ever since. Its most recent: a rapid antidepressant effect in treatment-resistant depression, appearing within hours rather than weeks, through a mechanism that has forced a revision of how the field thinks about antidepressant pharmacology.
The Science Behind Ketamine
Ketamine is a non-competitive NMDA receptor antagonist it enters the open channel and blocks ion flow. This blocks the excitatory glutamatergic signaling that NMDA receptors mediate, producing dissociative, amnestic, and analgesic effects useful in anesthesia. The rapid antidepressant effect (appearing within hours, lasting days to weeks after a single dose) appears to involve a different mechanism than simple NMDA blockade: evidence points to downstream effects on AMPA receptors and BDNF (brain-derived neurotrophic factor) signaling, with ketamine promoting synaptogenesis in prefrontal cortical circuits. This neuroplasticity hypothesis of rapid antidepressant action suggests that depression involves synaptic loss in prefrontal circuits, and that ketamine (and possibly other agents) can rapidly reverse this. Esketamine (the S-enantiomer) was FDA-approved for treatment-resistant depression in 2019, the first genuinely new antidepressant mechanism in decades.
A Meaningful Gift for Science Lovers
For anesthesiologists, psychiatrists, neuroscientists studying NMDA receptors or rapid antidepressant mechanisms, and anyone following the revolution in depression pharmacology.
- anesthesiologists and emergency physicians
- psychiatrists treating treatment-resistant depression
- neuroscientists studying NMDA receptors and neuroplasticity
- anyone following the ketamine-antidepressant story
The anesthetic that turned out to be the most important advance in depression treatment in thirty years.
Explore Related Molecules Jewelry
- Ketamine necklace | gold vermeil
- Ketamine propofol necklace H | silver
- Ketamine propofol necklace V | silver
- Propofol necklace | silver
- GABA necklace | silver
FAQ
Q: Is this a meaningful pendant for someone in anesthesiology?
A: Yes. Ketamine has revolutionized pain management and anesthesia. For anesthesiologists and pain specialists, this is a molecule with profound clinical importance.
Q: What's ketamine's role in medicine?
A: Ketamine was developed as a safer anesthetic than earlier drugs. Now it's used in pediatric anesthesia, pain management, and emerging psychiatry research. The molecule shown here has saved countless lives.
Q: What materials and sizing?
A: Sterling silver pendant, approximately 15-27 mm, on a 45cm chain. Check for other variants. Ships globally with DHL Express.
Q: Is this a good gift for an anesthesiologist?
A: Yes. It acknowledges their expertise in a molecule that defines modern anesthesia.
Molecules
Delve into the hidden elegance of science with our meticulously crafted jewelry, inspired by the intricate structures of chemical molecules. Each piece serves as a tactile tribute to the building blocks of life and matter, capturing the allure of atoms and bonds in precious metals. A harmonious fusion of art and science, these creations are more than mere accessories; they're a celebration of the enigmatic beauty that underpins our universe.
Find your perfect fit: measure an Existing Ring
Finding out your ring size at home is a simple process and can help you shop for jewelry online with confidence.
Necklace length guide
