serotonin necklace H

Serotonin necklace H | sterling silver

Serotonin (5-hydroxytryptamine) is the neurotransmitter that runs the moods of mood, the gut motility of digestion, and the platelet-aggregation switch of the bloodstream all from the same simple indole structure. The horizontal layout of the molecule reads as a quieter, more wearable version of the more familiar vertical pendant.

The Chemistry of Serotonin

Serotonin is a monoamine neurotransmitter synthesised from tryptophan via 5-hydroxytryptophan (5-HTP), with the rate-limiting step catalysed by tryptophan hydroxylase. About 90% of the body's serotonin is in the gut, where enterochromaffin cells regulate motility and secretion. The remaining 10% in the central nervous system arises mostly from the raphe nuclei in the brainstem, projecting widely to cortex, limbic system, and spinal cord. Modern psychiatry depends on the serotonin system: SSRIs (fluoxetine, sertraline, escitalopram), SNRIs, MAOIs, triptans for migraine (5-HT1B/1D agonists), 5-HT3 antagonists for chemo-induced nausea, atypical antipsychotics with 5-HT2A activity. The molecule is small, the receptor diversity is enormous (14 known subtypes), and the clinical reach extends from depression to nausea to migraine to autism research.

Worn By

The audience clusters around neuroscience and psychiatry:

• psychiatrists and clinical psychologists
• neuroscientists studying mood, anxiety, or reward circuits
• pharmacologists working on serotonergic drugs
• gastroenterologists studying gut motility and the enteric nervous system
• medical students and residents through psychiatry rotations

Often picked by partners or family of working psychiatrists and psychopharmacologists, with the horizontal layout chosen as the quieter daily-wear version of the vertical pendant.

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