€ 240
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Estrogen necklace 3D | 18K gold vermeil
Estradiol is the principal endogenous estrogen in mammals, the steroid hormone that drives reproductive development, bone maintenance, cardiovascular protection, and the receptor pharmacology behind ER-positive breast cancer therapy. The 18K gold vermeil version of the molecule, at 38 mm.
The Science Behind Estrogen
Estradiol (17β-estradiol, E2) is synthesised from cholesterol via a sequence of enzymatic steps, with aromatase converting androstenedione and testosterone into the corresponding estrogens. Estradiol binds two nuclear receptors, ERα and ERβ, with tissue-specific distribution that explains why selective receptor modulators (SERMs) like tamoxifen can act as estrogen agonists in bone and antagonists in breast tissue. Roughly 75% of breast cancers are ER-positive and depend on estrogen signalling for growth, which is why aromatase inhibitors and tamoxifen sit at the centre of adjuvant therapy. The Women's Health Initiative trial in 2002 reshaped how postmenopausal hormone replacement is prescribed, with the field continuing to refine the risk-benefit balance for early versus late initiation. The molecule's reach across reproductive biology, oncology, bone metabolism, and cardiovascular medicine is unusually broad for a single steroid.
Who Will Recognise It
- endocrinologists, gynaecologists, and reproductive medicine specialists
- breast oncologists and clinical trialists in hormone-receptor-positive cancer
- women's health researchers and bone metabolism specialists
- partners and family of working clinicians or researchers in hormone biology
Explore Related Molecules Jewelry
- Estrogen necklace | silver
- Testosterone necklace | silver
- Cortisol necklace | gold vermeil
- Oxytocin necklace | silver
FAQ
Gold or silver?
Same 38 mm pendant, same chain length, same molecule, also in sterling silver. Choose the finish the recipient already wears. Both versions carry the same design and the same meaning.
Why does estrogen matter in cancer treatment?
Because roughly three-quarters of breast cancers express estrogen receptors and depend on estrogen for growth. Tamoxifen, a selective estrogen receptor modulator, was the first drug developed specifically to block estrogen action in breast tissue and has been the backbone of ER-positive breast cancer therapy for fifty years. Aromatase inhibitors followed, blocking the synthesis of estrogen from androgen precursors. The clinical effect is dramatic: ER-positive cancers that were once highly recurrent are now among the more treatable solid tumours.
What size is the pendant and what chain comes with it?
18K gold vermeil over a sterling silver core, 38 mm pendant on a 45 cm gold vermeil chain with a 5 cm extender. Nickel-free and hypoallergenic. Free worldwide DHL Express in 1-5 business days, with all import duties and taxes covered. 30-day “Love It or Return It” returns.
Is there a silver version?
Yes. The same 38 mm estrogen pendant comes in sterling silver at the same chain length.
Molecules
Delve into the hidden elegance of science with our meticulously crafted jewelry, inspired by the intricate structures of chemical molecules. Each piece serves as a tactile tribute to the building blocks of life and matter, capturing the allure of atoms and bonds in precious metals. A harmonious fusion of art and science, these creations are more than mere accessories; they're a celebration of the enigmatic beauty that underpins our universe.
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