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Ketamine necklace | 18K gold vermeil
In 1962 Calvin Stevens at Parke-Davis synthesised a compound he hoped would be a shorter-acting dissociative than phencyclidine. In 2019 the FDA approved its S-enantiomer for treatment-resistant depression. Ketamine bookends two of the longest approval gaps in modern pharmacology. Worn here as a 27 mm 18K gold vermeil pendant.
The Science Behind Ketamine
Ketamine was first synthesised by Calvin Stevens at Parke-Davis in 1962, derived from phencyclidine and selected as a less-prolonged dissociative anaesthetic. It received FDA approval in 1970 and became a battlefield anaesthetic in Vietnam, valued because it preserves airway reflexes and cardiovascular tone where most other anaesthetics suppress them. The primary mechanism is non-competitive antagonism of the NMDA glutamate receptor, with secondary effects on AMPA, opioid, and monoaminergic systems. The S-enantiomer (esketamine) was approved by the FDA in 2019 as Spravato for treatment-resistant depression, the first new-mechanism antidepressant in decades. Sub-anaesthetic doses produce rapid antidepressant effects within hours, distinct from the weeks-to-months timeline of monoamine-targeting drugs.
Worn By
- anaesthesiologists at career milestones, especially those crossing into interventional psychiatry
- psychiatrists running ketamine or esketamine clinics
- residents finishing anaesthesiology, emergency medicine, or psychiatry training
- academic pharmacologists working on NMDA receptor biology and mood disorders
Most often given on residency completion in anaesthesia, emergency medicine, or psychiatry, or on the opening of a ketamine or esketamine clinic. The gold reads as recognition of the molecule's place at the boundary of two clinical specialties.
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FAQ
Why pick the gold ketamine over the silver?
Gold and silver mark different occasions. The gold ketamine reads as a milestone marker: anaesthesiology or psychiatry residency completion, board certification, the opening of a ketamine or esketamine practice. The silver ketamine is the working-day reference, picked by clinicians who use the molecule daily and want a quieter signal. Same 27 mm pendant, same chain length, same molecule. The choice marks the occasion.
What does ketamine sit between, anaesthesia or psychiatry?
Both, increasingly. The molecule was an anaesthetic for fifty years before the antidepressant action was developed clinically. Esketamine's 2019 FDA approval moved ketamine into mainstream psychiatry, with anaesthesiology-trained clinicians and psychiatrists running parallel clinics that look more alike than they used to. The gold pendant works for either community: a recognition piece for the residency that finishes, or for the practice that opens.
What size is the pendant and what chain comes with it?
18K gold vermeil over a sterling silver core, 27 mm pendant on a 45 cm gold vermeil chain (ø 1.8 mm) with a 5 cm extender. Nickel-free and hypoallergenic. Free worldwide DHL Express in 1-5 business days, with all import duties and taxes covered. 30-day “Love It or Return It” returns.
Is there a silver version?
Yes. The same ketamine pendant is available in sterling silver at the same 27 mm size and chain length. Many clinicians who own the gold version eventually pick up the silver for daily clinical wear.
Molecules
Delve into the hidden elegance of science with our meticulously crafted jewelry, inspired by the intricate structures of chemical molecules. Each piece serves as a tactile tribute to the building blocks of life and matter, capturing the allure of atoms and bonds in precious metals. A harmonious fusion of art and science, these creations are more than mere accessories; they're a celebration of the enigmatic beauty that underpins our universe.
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