€ 200
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Nucleosomes necklace | 18k gold vermeil
The nucleosome — DNA wrapped around histone proteins, the fundamental unit of chromatin packaging — in 18k gold vermeil.
Nucleosomes and Chromatin
Each nucleosome consists of 147 base pairs of DNA wrapped approximately 1.65 times around an octamer of histone proteins (two copies each of H2A, H2B, H3, and H4). Nucleosomes connected by linker DNA form the 'beads on a string' chromatin fibre visible by electron microscopy. Histone modifications — acetylation, methylation, phosphorylation, and ubiquitylation of specific residues on histone tails — constitute the histone code that regulates chromatin accessibility and gene expression. Histone deacetylase (HDAC) inhibitors and histone methyltransferase inhibitors are approved anticancer drugs, and epigenetic regulation via nucleosome remodelling is one of the most active areas in cancer biology.
A Meaningful Gift for Science Lovers
A refined piece for chromatin biologists, epigenetics researchers, and molecular oncologists.
- For a chromatin biologist or epigenetics researcher
- For a molecular oncologist working with HDAC inhibitors or other epigenetic therapies
- For a structural biologist who has studied the nucleosome crystal structure
- As a distinctive gold piece from the molecular biology collection
Comes in a gift box. Free worldwide shipping.
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FAQ
Q: Is this elegant enough for professional contexts?
A: Yes. The beads-on-a-string pattern reads as understated sophistication to most people, but carries full meaning to anyone in molecular biology, genetics, or structural biology.
Q: What happens when chromatin becomes too tightly wrapped?
A: Excessive nucleosome compaction silences genes through heterochromatin formation. In cancer, this is a problem: tumor suppressors get locked down by repressive chromatin marks, silencing them without DNA mutation. Many epigenetic drugs work by loosening this grip.
Q: What are the specs?
A: 41 mm pendant in 18k gold vermeil (sterling silver base with thick 18k gold plating), 45 cm gold vermeil chain with lobster clasp and 5 cm extender. Gift-ready packaging included. Ships within 1-5 business days via DHL Express.
Q: Is the silver version available?
A: Yes, if you prefer the cooler tone of silver instead of gold. Same design, different finish. Both are nickel-free.
Human Anatomy
Anatomical wonders have never been so elegantly articulated. Our anatomical collection embodies the intricate and awe-inspiring structures that make us who we are. From DNA double helices to neuronal networks, our pieces don't merely imitate—they interpret. The collection serves as a tangible tribute to the hidden beauty within us all, elevating the realms of biology and medicine into wearable art. With exquisite attention to detail, each piece is a dialogue between form and function, revealing the enigmatic eloquence of the human body.
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