GABA necklace

GABA necklace | gold vermeil

Gamma-aminobutyric acid in 18K gold vermeil at 26 mm. The brain's main inhibitory neurotransmitter, the molecule benzodiazepines and barbiturates work through, the system ethanol and propofol reach. For people whose work involves keeping the nervous system calm, the molecule is unmistakable.

The Science Behind GABA

GABA is the principal inhibitory neurotransmitter in the mammalian central nervous system, present in roughly 30 percent of all synapses. It is synthesised from glutamate by glutamic acid decarboxylase and acts at two main receptor classes: GABA-A receptors are ligand-gated chloride channels that hyperpolarise the postsynaptic neuron, and GABA-B receptors are G-protein-coupled receptors that produce slower inhibitory effects. Benzodiazepines, barbiturates, alcohol, propofol, and most general anaesthetics potentiate GABA-A signalling, which is why they all produce sedation and anxiolysis. Loss of GABAergic inhibition is implicated in epilepsy, anxiety disorders, and Huntington's disease, where degeneration of GABAergic medium spiny neurons in the striatum drives the motor symptoms.

Who Reaches For This

People whose professional or personal life involves the inhibitory side of the nervous system.

• neuroscientists and neuropharmacologists
• anaesthesiologists and intensivists
• epileptologists and neurologists
• psychiatrists and addiction medicine clinicians

Explore Related Molecules Jewelry

• GABA necklace | silver
• Serotonin necklace V | gold vermeil
• Dopamine necklace V | gold vermeil
• Dopamine bracelet | silver
• Neuron necklace | silver

Frequently Asked Questions

Why GABA rather than a more famous neurotransmitter?

Because dopamine and serotonin get most of the visibility, but GABA does most of the inhibitory work in the brain. People who reach for the GABA pendant tend to be those who think about the brain in terms of balance: excitation versus inhibition, glutamate versus GABA. The molecule sits on the inhibitory side of that balance.

Who is the typical recipient?

Anaesthesiologists, neuropharmacologists, and epileptologists are the three groups that order this most. The piece is also chosen by patients with personal experience of GABAergic medications and by neuroscience graduate students working on inhibitory circuits.

What are the specs and what is the return policy?

18K gold vermeil with sterling silver core and 2.5 micron gold plating, 26 mm pendant, 45 cm chain with a 5 cm extender. Nickel-free and hypoallergenic. Ships free worldwide via DHL Express in 1-5 business days, with all import duties and taxes covered. 30-day “Love It or Return It” returns.

Is this also available in silver?

Yes. A GABA pendant in 925 sterling silver is available in the same molecular form. The catalog also includes serotonin and dopamine pendants for people who want to extend the neurotransmitter set.