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shRNA necklace H | sterling silver
Small hairpin RNA folds back on itself into a tight loop. When delivered by viral vectors into cells, it is processed by Dicer into siRNA and loaded into RISC, silencing target genes on demand. It is the molecular tool that made functional genomics systematic and real.
The Science Behind shRNA
Short hairpin RNA (shRNA) is a synthetic RNA structure containing a loop that can be processed by endogenous RNA machinery. Delivered via viral vectors (lentiviral, adenoviral), shRNAs are cleaved by Drosha and Dicer into siRNA duplexes, which are loaded into the RISC complex to direct mRNA cleavage. Unlike transient siRNA transfection, shRNA-based silencing is stable and heritable, enabling long-term gene knockdown in cell lines and animal models. Genome-scale shRNA libraries enabled the first large-scale functional screens in mammalian cells, revealing genes essential for cell survival and disease progression.
Who Will Recognise It
- molecular biologists using RNA interference in their work
- researchers who have run genome-scale shRNA screens
- RNA biologists and functional genomics specialists
- anyone working in gene silencing or therapeutic RNAi
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FAQ
Who wears the shRNA necklace?
Molecular biologists and geneticists whose work relies on RNA interference. If you have designed an shRNA, transfected cells with it, or run a genome-scale shRNA screen, this structure is instantly recognizable.
What makes shRNA different from siRNA?
siRNA is transient (delivered as short double-stranded RNA, degraded after several rounds of silencing). shRNA is stable (expressed from a vector, processed by cellular enzymes, heritable through cell divisions). For long-term, stable gene knockdown in model systems, shRNA is the tool of choice. Therapeutic RNAi drugs like patisiran (FDA 2018) use modified siRNA, while research-grade shRNA libraries remain the standard in functional genomics.
What's the material, size, and chain?
35 mm pendant in 925 polished sterling silver, nickel-free and hypoallergenic. 45 cm sterling silver chain with lobster clasp and 5 cm extender. High-polish finish. Comes in a ready-to-gift, eco-friendly jewelry box with the 30-day “Love It or Return It” policy. Free worldwide DHL Express shipping (1-5 business days).
Is there a gold version?
Yes. The shRNA necklace H is available in 18k gold vermeil. Same size, same chain style, different material. The silver version is the daily-wear piece.
Cellular Biology
Step into the fascinating world of cellular biology through our unique jewelry designs. These pieces serve as wearable reflections of life's microscopic wonders, capturing the aesthetics of DNA strands, cellular formations, and more. Far from simple adornments, they spark dialogue and honor the captivating complexities found within biological research. Merging scientific accuracy with artistic flair, each creation offers a tactile experience that bridges the gap between scientific inquiry and aesthetic appreciation.
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